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Biological oxidations
The broad source hierarchy for oxidative and conjugative transformations of diverse small molecules. 194 reactions, from Reactome R-HSA-211859.
- CNDP2:2Mn2+ dimer hydrolyses CysGlyCysGly + H2O → L-Cys + Gly
- GSH translocates from cytosol to extracellular regionGSH → GSH
- GGCT transforms gGluCys to OPROgGluCys → L-Cys + OPRO
- OPLAH hydrolyses OPRO to L-GluATP + 2 H2O + OPRO → ADP + L-Glu + Pi
- CysGly translocates from extracellular region to cytosolCysGly → CysGly
- FMO3:FAD N-oxidises TMA to TMAOTMA + O2 + NADPH + H+ → TMAO + H2O + NADP+
- Arachidonate is oxidised to PGG2 by PTGS12 O2 + AA → PGG2
- PGG2 is reduced to PGH2 by PTGS1PGG2 + hydrogen donor → H2O + PGH2 + hydrogen acceptor
- MAOA:FAD oxidatively deaminates of 5HTO2 + H2O + 5HT → 5HIALD + H2O2 + NH4+
- MAOB:FAD oxidatively deaminates of PEAPEA + H2O + O2 → Phenylacetaldehyde + NH3 + H2O2
- MAOB:FAD oxidatively deaminates TYRTYR + H2O + O2 → HPHAC + NH3 + H2O2
- SMOX-3 oxidises SPN to SPMSPN + H2O + O2 → SPM + 3APAL + H2O2
- PAO:FAD oxidises NASPM to PTCNNASPM + H2O + O2 → PTCN + H2O2 + 3AAPNAL
- PAOX:FAD oxidises NASPN to SPMNASPN + H2O + O2 → SPM + H2O2 + 3AAPNAL
- MEOS oxidizes ethanol to acetaldehydeEtOH + NADPH + H+ + O2 → CH3CHO + 2 H2O + NADP+
- CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBOAFB1 + H+ + NADPH + O2 → AFXBO + H2O + NADP+
- SULT1A1 dimer sulfonates PARA to PARA-SO4PAPS + APAP → PARA-SO4 + PAP
- TPMT transfers CH3 from AdoMet to 6MP6MP + AdoMet → 6MMP + AdoHcy + H+
- The acetyl group from acetyl-CoA is transferred to NAT2NAT2 + Ac-CoA → AcC-NAT2 + CoA-SH
- Phenol can form a sulfate conjugatePhOH + PAPS → Phenyl sulfate + PAP
- SULT1A1 dimer sulfonates NHABPNHABP + PAPS → NHABP-SO4 + PAP
- UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDGBMG + UDP-GlcA → BDG + UDP
- UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMGBIL + UDP-GlcA → BMG + UDP
- SULT1A3,4 dimers sulfate DA to DAOSDA + PAPS → DAOS + PAP
- benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphateBENZA + ATP + CoA-SH → BEZ-CoA + AMP + PPi
- benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme ABEZ-CoA + Gly → HIPA + CoA-SH
- ACSM2B-like proteins transform ST to ST-CoAST + ATP + CoA-SH → ST-CoA + AMP + PPi
- GLYAT-like proteins transfer glycine to ST-CoA to form SUAST-CoA + Gly → SUA + CoA-SH
- UDP-glucose is oxidised to UDP-glucuronateUDP-Glc + 2 NAD+ + H2O → UDP-GlcA + 2 NADH + 3 H+
- GCL ligates L-Glu to L-CysL-Glu + L-Cys + ATP → gGluCys + ADP + Pi
- SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumenUDP-GlcA + UDP-GlcNAc → UDP-GlcA + UDP-GlcNAc
- MTR transfers CH3 from MeCbl to HCYSMTRR:MTR:MeCbl + HCYS → MTRR:MTR:cob(I)alamin + L-Met
- MAT1A multimers transfer Ado from ATP to L-MetATP + L-Met + H2O → AdoMet + Pi + PPi
- GSS:Mg2+ dimer synthesizes GSHgGluCys + Gly + ATP → GSH + ADP + Pi
- AHCY:NAD+ tetramer hydrolyses AdoHcyAdoHcy + H2O → HCYS + Ade-Rib
- Formation of N-glucuronidesUDP-GlcA + N-centre functional group substrate → UDP + N-glucuronide
- UGTs transfer GlcA from UDP-GlcA to O-centre substratesO-centre functional group substrate + UDP-GlcA → O-glucuronide + UDP
- The acetyl group from acetyl-CoA is transferred to NAT1NAT1 + Ac-CoA → AcC-NAT1 + CoA-SH
- NAT1 acetylationNAT1 substrate + AcC-NAT1 → NAT1 acetylated conjugate + NAT1
- NAT2 acetylationNAT2 substrate + AcC-NAT2 → NAT2 acetylated conjugate + NAT2
- TMT transfers CH3 from AdoMet to BMEBME + AdoMet → MMETOH + AdoHcy
- COMT transfer CH3 from AdoMet to 3,4DHBNZ3,4DHBNZ + AdoMet → AdoHcy + 3H,4MBNZ
- NNMT transfers CH3 from AdoMet to PYPY + AdoMet → AdoHcy + MP+
- GST dimers conjugate GSH with cytosolic substratesGSH + Electrophilic substrate → electrophilic substrate:SG
- GST trimers transfer GS from GSH to luminal substrateselectrophilic substrate + GSH → electrophilic substrate:SG
- 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP3,3'-diiodothyronine + PAPS → 3,3'-diiodothyronine 4-sulfate + PAP
- SULTs transfer (SO4)2- group to 27HCHOL27HCHOL + PAPS → 27HCHOL3S + PAP
- SULTs transfer (SO4)2- group to PREGPREG + PAPS → PREGS + PAP
- beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAPPAPS + EST17b → PAP + E2-SO4
- 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAPT3 + PAPS → 3,5,3'-triiodothyronine 4-sulfate + PAP
- lithocholate + PAPS => lithocholate sulfate + PAPPAPS + LCA → PAP + lithocholate sulfate
- taurolithocholate + PAPS => taurolithocholate sulfate + PAPPAPS + taurolithocholate → PAP + taurolithocholate sulfate
- Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphatePAP + H2O → AMP + Pi
- cholesterol + PAPS => cholesterol sulfate + PAPPAPS + CHOL → PAP + cholesterol sulfate
- dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAPPAPS + DHEA → PAP + DHEA-SO4
- p-nitrophenol + PAPS => p-nitrophenol sulfate + PAPPAPS + PNP → PAP + p-nitrophenol sulfate
- estrone + PAPS => estrone 3-sulfate + PAPPAPS + E1 → PAP + E1S
- N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAPN-hydroxy-2-acetylaminofluorene + PAPS → AAF-N-S + PAP
- phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphatephenylacetate + ATP + CoA-SH → phenylacetyl-CoA + AMP + PPi
- phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme Aphenylacetyl-CoA + L-Gln → phenylacetyl glutamine + CoA-SH
- CYP7A1 7-hydroxylates CHOLCHOL + NADPH + H+ + O2 → H2O + NADP+ + 7 alpha-hydroxycholesterol
- CYP46A1 24-hydroxylates CHOLCHOL + NADPH + H+ + O2 → 24OH-CHOL + NADP+ + H2O
- CYP7B1 7-hydroxylates 25OH-CHOL25OH-CHOL + NADPH + H+ + O2 → CHOL3b,7a,25TRIOL + H2O + NADP+
- CYP27A1 27-hydroxylates CHOLCHOL + NADPH + H+ + O2 → 27OH-CHOL + H2O + NADP+
- CYP8B1 12-hydroxylates 4CHOL7aOLONE4CHOL7aOLONE + NADPH + H+ + O2 → 4CHOL7a,12aDONE + NADP+ + H2O
- CYP39A1 7-hydroxylates 24OH-CHOL24OH-CHOL + O2 + hydrogen donor → CHOL7a,24(S)DIOL + H2O + hydrogen acceptor + H+
- CYP19A1 hydroxylates ANDST to E1ANDST + 3 NADPH + 3 H+ + 3 O2 → 4 H+ + E1 + 3 NADP+ + 4 H2O + HCOOH
- CYP11A1 cleaves 20a,22b-DHCHOL20a,22b-DHCHOL + O2 + 2 CYP11A1:FDXR:FDX1,FDX1L (red.) + 2 NADPH + 2 H+ → PREG + ISCAL + 2 H2O + 2 CYP11A1:FDXR:FDX1,FDX1L (ox.) + 2 NADP+
- CYP8B1 12-hydroxylates 4CHOL7a,27DONE4CHOL7a,27DONE + NADPH + H+ + O2 → 4CHOL7a,12a,27TONE + NADP+ + H2O
- CYP21A2 21-hydroxylates PROGP4 + NADPH + H+ + O2 → 11DCORST + NADP+ + H2O
- CYP11B2 oxidises 18HCORST to ALDO18HCORST + 2 NADPH + 2 H+ + O2 → ALDO + 2 NADP+ + 2 H2O
- CYP11B2 18-hydroxylates CORST to 18HCORSTCORST + 2 NADPH + 2 H+ + O2 → 18HCORST + 2 NADP+ + H2O
- CYP11B1 oxidises 11DCORT11DCORT + 2 NADPH + 2 H+ + O2 → CORT + 2 NADP+ + H2O
- CYP11B2 oxidises 11DCORST to CORST11DCORST + 2 NADPH + 2 H+ + O2 → CORST + H2O + 2 NADP+
- CYP51A1 demethylates LANLAN + 3 H+ + 3 NADPH + 3 O2 → 4,4DMCHtOL + HCOOH + 4 H2O + 3 NADP+
- CYP2R1 25-hydroxylates VD3 to 25(OH)DVD3 + O2 + H+ + NADPH → 25(OH)D + H2O + NADP+
- CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D25(OH)D + H+ + NADPH + O2 → 1,25(OH)2D + H2O + NADP+
- CYP4F2, 4F3 20-hydroxylate LTB4LTB4 + NADPH + H+ + O2 → 20OH-LTB4 + H2O + NADP+
- CYP2S1 4-hydroxylates atRAatRA + NADPH + H+ + O2 → 4OH-atRA + NADP+ + H2O
- Coumarin is 7-hydroxylated by CYP2A13COUM + O2 + NADPH + H+ → HCOU + H2O + NADP+
- CYP3A7 can 6beta-hydroxylate testosteroneTES + NADPH + H+ + O2 → 6BHT + H2O + NADP+
- CYP4F12 18-hydroxylates ARAAA + O2 + NADPH + H+ → 18OH-ARA + H2O + NADP+
- CYP2C8 inactivates paclitaxel by 6alpha-hydroxylationPTXL + O2 + NADPH + H+ → HPTXL + H2O + NADP+
- CYP4F8 19-hydroxylates PGH2PGH2 + NADPH + H+ + O2 → NADP+ + H2O + 19OH-PGH2
- CYP26C1 4-hydroxylates 9cRA9cRA + NADPH + H+ + O2 → 4OH-9cRA + NADP+ + H2O
- CYP4B1 12-hydroxylates ARAAA + H+ + NADPH + O2 → 12-HETE + NADP+ + H2O
- CYP2C19 5-hydroxylates omeprazoleLosec + NADPH + H+ + O2 → HOMZ + NADP+ + H2O
- CYP3A4 can N-demethylate loperamideLPAM + H+ + NADPH + O2 → N-demethylated loperamide + H2O + NADP+
- CYP24A1 24-hydroxylates CTLCTL + NADPH + H+ + O2 → CTLA + NADP+ + H2O
- CYP1B1 4-hydroxylates EST17bEST17b + H+ + NADPH + O2 → 4OH-EST17b + H2O + NADP+
- CYP3A43 6b-hydroxylates TESTTES + NADPH + H+ + O2 → H2O + NADP+ + 6BHT
- CYP2U1 19-hydroxylates ARAAA + NADPH + H+ + O2 → 19HETE + H2O + NADP+
- CYP4F11 16-hydroxylates 3OH-PALM3OH-PALM + NADPH + H+ + O2 → 3,16DOH-PALM + NADP+ + H2O
- CYP2D6 4-hydroxylates debrisoquineDSQ + O2 + NADPH + H+ → HDBQ + H2O + NADP+
- CYP2W1 oxidises INDOLINDOL + NADPH + H+ + O2 → Oxindole + NADP+ + H2O
- CYP2J2 oxidises ARAAA + NADPH + H+ + O2 → cis-EET + NADP+ + H2O
- CYP2C9 inactivates tolbutamide by 4methyl-hydroxylationO2 + NADPH + H+ + TBM → HTOLB + H2O + NADP+
- Cyclophosphamide is 4-hydroxylated by CYP2B6CPM + O2 + NADPH + H+ → HCPM + H2O + NADP+
- CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylationPhenytoin + O2 + NADPH + H+ → HPHT + H2O + NADP+
- CYP2F1 dehydrogenates 3-methylindoleMIND + H+ + NADPH + O2 → 3MEIN + H2O + NADP+
- CYP26A1,B1 4-hydroxylate atRAatRA + NADPH + H+ + O2 → 4OH-atRA + H2O + NADP+
- CYP3A4,5 oxidise AFB1 to AFXBOAFB1 + O2 + NADPH + H+ → AFXBO + H2O + NADP+
- CYP4F3 20-hydroxylates LTB4LTB4 + NADPH + H+ + O2 → 20OH-LTB4 + H2O + NADP+
- FMO1:FAD N-oxidises TAMO2 + NADPH + H+ + TAM → TAMO + H2O + NADP+
- FMO2:FAD:Mg2+ S-oxidises MTZMTZ + NADPH + H+ + O2 → MTZ-SOX + NADP+ + H2O
- GSTK1 dimer transfers GS from GSH to CDNBCDNB + GSH → DNPSG + HCl
- acetaldehyde [cytosolic] => acetaldehyde [mitochondrial]CH3CHO → CH3CHO
- acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]ATP + CH3COO- + CoA-SH → Ac-CoA + AMP + PPi
- AFXBO binds DNAAFXBO + DNA → AFXBO:DNA
- AKR dimers reduce AFBDHO to AFBDOHNADPH + H+ + AFBDHO → NADP+ + AFBDOH
- CYP2A13 oxidises AFM1 to AFM1EAFM1 + H+ + NADPH + O2 → AFM1E + H2O + NADP+
- MGST trimers transfer GS from GSH to AFXBO and AFNBOAFXBO,AFNBO + GSH → AFXBO-SG,AFNBO-SG
- AFXBO hydrolyses non-enzymatically to AFBDHDH2O + AFXBO → AFBDHD
- CYP3A4,5 hydroxylates AFB1 to AFQ1AFB1 + NADPH + O2 + H+ → AFQ1 + H2O + NADP+
- CYP1A2, 3A4 oxidise AFB1 to AFNBOAFB1 + H+ + NADPH + O2 → AFNBO + H2O + NADP+
- CYP1A2 hydroxylates AFB1 to AFM1AFB1 + H+ + NADPH + O2 → AFM1 + H2O + NADP+
- AFBDHD hydrolyses non-enzymatically to AFBDHOAFBDHD + H2O → AFBDHO
- AFXBO translocates from cytosol to nucleoplasmAFXBO → AFXBO
- Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-CAFXBO-C,AFNBO-C + Ac-CoA → CoA-SH + AFXBO-NAC,AFNBO-NAC + H+
- DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CGAFXBO-CG,AFNBO-CG → AFXBO-C,AFNBO-C + Gly
- GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SGAFXBO-SG,AFNBO-SG + H2O → AFXBO-CG,AFNBO-CG + L-Glu
- ACY1:Zn2+ dimer hydrolyses mercapturic acidsAFXBO-NAC,AFNBO-NAC + H2O → AFXBO-C,AFNBO-C + acetate
- AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular regionAFXBO-SG,AFNBO-SG → AFXBO-SG,AFNBO-SG
- AFXBO-C, AFNBO-C translocate from extracellular region to cytosolAFXBO-C,AFNBO-C → AFXBO-C,AFNBO-C
- CYP4F22 20-hydroxylates TrXA3H+ + NADPH + O2 + TrXA3 → H2O + NADP+ + 20OH-TrXA3
- MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-MetATP + L-Met + H2O → AdoMet + Pi + PPi
- AADAC deacetylates PHENPHEN + H2O → 4-ethoxyaniline + acetyl group
- AKR1A1 oxidises BaPtDHD to BaP-7,8-dioneBaPtDHD + NADP+ → NADPH + BaP-7,8-dione
- ADH5 oxidises S-HMGSH to S-FGSHNAD+ + S-HMGSH → S-FGSH + H+ + NADH
- ALD3A1 oxidises 4HPCP to CXPA4HPCP + H2O + NADP+ → CXPA + H+ + NADPH
- CES1 trimer.CES2 hydrolyse COCN to BEGH2O + COCN → BEG + MeOH + H+
- ESD dimer hydrolyses S-FGSH to GSHS-FGSH + H2O → GSH + formate
- EPHX1 hydrates BaP4,5O to BaP4,5-DHDBaP4,5O + H2O → BaP4,5-DHD
- ABHD10 hydrolyses MPAGAMPAG + H2O → MPA + GlcA
- ABHD14B hydrolyses PNPBPNPB + H2O → PNP + BUT
- ALDH1B1 tetramer oxidises CH3CHO to CH3COOHCH3CHO + H2O + NAD+ → CH3COO- + H+ + NADH
- AOC1 deaminates HistHist + H2O + O2 → I4AH + NH3 + H2O2 + H+
- AOC2 deaminates TYRTYR + H2O + O2 → 4HPAA + NH3 + H2O2 + H+
- AOC3 deaminates BZAMBZAM + H2O + O2 → NH3 + H2O2 + H+ + BZAL
- AS3MT transfers CH3 from AdoMet to methylarsonitemethylarsonite + AdoMet → dimethylarsinate + AdoHcy
- AS3MT transfers CH3 from AdoMet to arsenite(3-)arsenite(3-) + AdoMet → methylarsonate + AdoHcy
- GSTO1 dimer reduces methylarsonate to methylarsonitemethylarsonate + 2 GSH → methylarsonite + GSSG + H2O
- BPHL hydrolyses VACV to ACVVACV + H2O → ACV + L-Val
- CHAC1,2 cleaves GSH to OPRO and CysGlyGSH → OPRO + CysGly
- CMBL hydrolyses OM to OLMSOM + H2O → diketone + OLMS
- CYP4V2 omega-hydroxylates DHA to HDoHEDHA + H+ + NADPH + O2 → HDoHE + H2O + NADP+
- N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIIIMMAIII + AdoMet → DMAA + AdoHcy
- UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucoseUTP + G1P + H+ → PPi + UDP-Glc
- acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]CH3CHO + NAD+ + H2O → CH3COO- + NADH + H+
- ethanol + NAD+ => acetaldehyde + NADH + H+EtOH + NAD+ → CH3CHO + NADH + H+
- acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]CH3CHO + H2O + NAD+ → CH3COO- + H+ + NADH
- acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]ATP + CH3COO- + CoA-SH → AMP + PPi + Ac-CoA
- Vinyl chloride is oxidized to 2-Chloroethylene oxideVC + NADPH + H+ + O2 → H2O + NADP+ + 2CEO
- N-hydroxylation of 4-aminobiphenylABPH + O2 + NADPH + H+ → NHABP + H2O + NADP+
- CYP1A2 S-demethylates 6MMP6MMP + NADPH + H+ + O2 → 6MP + H2O + CH2O + NADP+
- Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)Acetaminophen (TN TYLENOL) + NADP+ + H2 + O2 → NABQI + H2O + NADPH
- Benzene is hydroxylated to phenolC6H6 + O2 + NADPH + H+ → PhOH + H2O + NADP+
- N-atom dealkylation of caffeineCAF + O2 + NADPH + H+ → Paraxanthine + H2O + NADP+ + CH2O
- Dehalogenation of carbon tetrachloride to form a free radicalCCl4 → Trichloromethyl radical + Cl-
- Coumarin is 7-hydroxylated by CYP2A6COUM + O2 + NADPH + H+ → HCOU + H2O + NADP+
- O-atom dealkylation of dextromethorphanDEXM + NADPH + O2 + H+ → DEXT + H2O + NADP+ + CH2O
- CYP4A11 omega-hydroxylates DDCXDDCX + O2 + NADPH + H+ → 12OH-DDCX + H2O + NADP+
- Ethylene is oxidized to Ethylene oxide by CYP1A1C2H4 + O2 + NADPH + H+ → EtO + H2O + NADP+
- Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromideHALO + NADPH + H+ + O2 → TFAC + HBr + NADP+ + H2O
- POR reduces CYP450:Fe3+ to CYP450:Fe2+NADPH + 2 CYP450:Fe3+ → NADP+ + 2 CYP450:Fe2+ + H+
- PTGIS, CYP8A1 isomerise PGH2 to PGI2PGH2 → PGI2
- TBXAS1 isomerises PGH2 to TXA2PGH2 → TXA2
- UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xyloseUDP-GlcA + H+ → UDP-Xyl + CO2
- MARC1,MARC2 reduce N-hydroxylated compoundsNOHA + H+ + NADH → L-Arg + NAD+ + H2O
- NQO2:FAD dimer reduces quinones to hydroquinonesquinone + RFDHN → hydroquinone + RFNA
- AHR:2xHSP90:AIP:PTGES3 binds TCDDAHR:2xHSP90AB1:AIP:PTGES3 + TCDD → AHR:TCDD:2xHSP90AB1:AIP:PTGES3
- AHRR binds ARNTAHRR + ARNT, ARNT2 → AHRR:ARNT
- AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasmAHR:TCDD:2xHSP90AB1:AIP:PTGES3 → AHR:TCDD:2xHSP90AB1:AIP:PTGES3
- AHR:TCDD binds ARNTAHR:TCDD + ARNT, ARNT2 → AHR:TCDD:ARNT
- AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociatesAHR:TCDD:2xHSP90AB1:AIP:PTGES3 → AHR:TCDD + 2xHSP90AB1:AIP:PTGES3
- CBR3 reduces DOX to DOXOLNADPH + doxorubicin → DOXOL + NADP+
- CES3 hydrolyses CHEST to CHOL and LCFA(-)H2O + CHEST → CHOL + LCFA(-)
- UGT1A10 transfers GlcA from UDP-GlcA to GCTNGCTN + UDP-GlcA → GCTN4OG + UDP
- GGT dimers hydrolyse GSHGSH + H2O → CysGly + L-Glu
- IMPAD1 hydrolyses PAP to AMPPAP + H2O → adenosine 5'-monophosphate + Pi
- TPST1,2 transfer SO4(2-) from PAPS to PODXL2PODXL2 + 2 PAPS → OSulf-Y97,118-PODXL2 + 2 PAP
- UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDGBMG + UDP-GlcA → BDG + UDP
- UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMGBIL + UDP-GlcA → BMG + UDP
- ACY3:Zn2+ dimer hydrolyses mercapturic acidsAFXBO-NAC,AFNBO-NAC + H2O → AFXBO-C,AFNBO-C + acetate
- MAOA inhibitors bind MAOA:FADMAOA:FAD + MAOA Inhibitors → MAOA:FAD:MAOA Inhibitors
- MAOB inhibitors bind MAOB:FADMAOB:FAD + MAOB Inhibitors → MAOB:FAD:MAOB Inhibitors
- CYP3A4 binds CYP3A4 inhibitorsCYP3A4 + CYP3A4 inhibitors → CYP3A4:CYP3A4 inhibitors
- CYP3A4, CYP2B6 bind ritonavirCYP3A4, CYP2B6 + ritonavir → CYP3A4,CYP2B6:ritinovir
- SLC35D2 exchanges UDP-GlcA for UMPUDP-GlcA + UMP → UDP-GlcA + UMP
- GLYAT-like proteins transfer glycine to phenylacetyl-CoAGly + phenylacetyl-CoA → CoA-SH + phenylacetyl-Gly + H+
- Unknown CYP 450 omega-hydroxylates C10 fatty acidO2 + NADPH + DECA → H2O + NADP+ + 10-OH-DECA + H+
- ADH7 dehydrogenates 10-OH-DECANAD+ + 10-OH-DECA → 10-oxo-DECA + NADH + H+
- Unknown ALDH oxidizes 10-oxo-DECAH2O + 10-oxo-DECA + NAD+ → 2 H+ + sebacate + NADH
- GLYAT-like proteins transfer glycine to aminobenzoyl-CoAGly + PABA-CoA → CoA-SH + PAH + H+