acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
CH3CHO + H2O + NAD+ → CH3COO- + H+ + NADH
- Reactome
- R-HSA-71723
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:25295
Inputs
- CH3CHOCHEBI:15343, C2H4O, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
Outputs
- CH3COO-CHEBI:30089, C2H3O2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
Catalysed by
- aldehyde dehydrogenase (NAD+) activity of ALDH2 tetramer [mitochondrial matrix]EC 1.2.1.3
Literature
- Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Biochim Biophys Acta, 1977
- Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. Eur J Biochem, 1985
- Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms Protein Sci, 1999