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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FMO3:FAD N-oxidises TMA to TMAO

TMA + O2 + NADPH + H+ → TMAO + H2O + NADP+

Reactome: R-HSA-139970
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: RHEA:31980

Inputs

TMACHEBI:18139, C3H9N, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen

Outputs

TMAOCHEBI:15724, C3H9NO, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

N,N-dimethylaniline monooxygenase activity of FMO3:FAD [endoplasmic reticulum membrane]EC 1.14.13.8

Literature

Trimethylamine N-oxide synthesis: a human variant Biochem Med, 1972
Trimethylaminuria: the fish-odour syndrome Lancet, 1970
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication Hum. Mol. Genet., 1998
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Nat. Med., 2013