CYP2D6 4-hydroxylates debrisoquine

DSQ + O2 + NADPH + H+ → HDBQ + H2O + NADP+

Reactome

R-HSA-211966

Compartment

endoplasmic reticulum membrane · endoplasmic reticulum lumen

Rhea

None recorded

Catalysed by

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom…EC 1.14.14.1

Literature

1. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine Proc Natl Acad Sci U S A, 1993
2. Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man Mol Pharmacol, 1983