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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP11B2 oxidises 18HCORST to ALDO

18HCORST + 2 NADPH + 2 H+ + O2 → ALDO + 2 NADP+ + 2 H2O

Reactome: R-HSA-193965
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:50793

Inputs

18HCORSTCHEBI:16485, C21H30O5, mitochondrial matrix
2 NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix
O2CHEBI:15379, O2, mitochondrial matrix

Outputs

ALDOCHEBI:27584, C21H28O5, mitochondrial matrix
2 NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
2 H2OCHEBI:15377, H2O, mitochondrial matrix

Catalysed by

steroid hydroxylase activity of CYP11B2 [mitochondrial inner membrane]UniProt P19099

Literature

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) J Biol Chem, 1989
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism Biochem Biophys Res Commun, 1990