benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate
BENZA + ATP + CoA-SH → BEZ-CoA + AMP + PPi
- Reactome
- R-HSA-159443
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:10133
Inputs
- BENZACHEBI:30746, C7H6O2, mitochondrial matrix
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
Outputs
- BEZ-CoACHEBI:57369, C28H36N7O17P3S, mitochondrial matrix
- AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
- PPiCHEBI:33019, HO7P2, mitochondrial matrix
Catalysed by
- CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
Literature
- Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria J Biochem Mol Toxicol, 2003
- Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids Biochim Biophys Acta, 1999