Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ADH5 oxidises S-HMGSH to S-FGSH

NAD+ + S-HMGSH → S-FGSH + H+ + NADH

Reactome: R-HSA-5692237
Compartment: cytosol
Rhea: RHEA:19986

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, cytosol
S-HMGSHCHEBI:48926, C11H19N3O7S, cytosol

Outputs

S-FGSHCHEBI:16225, C11H17N3O7S, cytosol
H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Catalysed by

S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity of ADH5:2xZn2+ dimer [cytosol]EC 1.1.1.284

ADH5 oxidises S-HMGSH to S-FGSH

Inputs

Outputs

Catalysed by

Literature