Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP8B1 12-hydroxylates 4CHOL7a,27DONE

4CHOL7a,27DONE + NADPH + H+ + O2 → 4CHOL7a,12a,27TONE + NADP+ + H2O

Reactome: R-HSA-193845
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

4CHOL7a,27DONECHEBI:48825, C27H44O3, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

4CHOL7a,12a,27TONECHEBI:48833, C27H44O4, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]EC 1.14.14.139; UniProt Q9UNU6

CYP8B1 12-hydroxylates 4CHOL7a,27DONE

Inputs

Outputs

Catalysed by

Literature