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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP39A1 7-hydroxylates 24OH-CHOL

24OH-CHOL + O2 + hydrogen donor → CHOL7a,24(S)DIOL + H2O + hydrogen acceptor + H+

Reactome: R-HSA-192178
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:46125

Inputs

24OH-CHOLCHEBI:34310, C27H46O2, endoplasmic reticulum membrane
O2CHEBI:15379, O2, cytosol
hydrogen donorCHEBI:17499, H2A, cytosol

Outputs

CHOL7a,24(S)DIOLCHEBI:37640, C27H46O3, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol
hydrogen acceptorCHEBI:13193, A, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

oxysterol 7-alpha-hydroxylase activity of CYP39A1 [endoplasmic reticulum membrane]UniProt Q9NYL5

Literature

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol J Biol Chem, 2000