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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SMOX-3 oxidises SPN to SPM

SPN + H2O + O2 → SPM + 3APAL + H2O2

Reactome: R-HSA-141341
Compartment: peroxisomal matrix · cytosol
Rhea: RHEA:25805

Inputs

SPNCHEBI:45725, C10H30N4, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix
O2CHEBI:15379, O2, peroxisomal matrix

Outputs

SPMCHEBI:57834, C7H22N3, peroxisomal matrix
3APALCHEBI:58374, C3H8NO, peroxisomal matrix
H2O2CHEBI:16240, H2O2, peroxisomal matrix

Catalysed by

spermine oxidase activity of SMOX-3 [cytosol]EC 1.5.3.16; UniProt Q9NWM0

Literature

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin Biochem J, 2002
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO Biochem Biophys Res Commun, 2003