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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CBR3 reduces DOX to DOXOL

NADPH + doxorubicin → DOXOL + NADP+

Reactome: R-HSA-8937419
Compartment: cytosol
Rhea: None recorded

Inputs

NADPHCHEBI:57783, C21H26N7O17P3, cytosol
doxorubicinR-ALL-9659674, cytosol

Outputs

DOXOLCHEBI:133817, C27H31NO11, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

carbonyl reductase (NADPH) activity of CBR3 [cytosol]EC 1.1.1.184; UniProt O75828

Literature

Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3 Chem. Biol. Interact., 2015
Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol Proc. Natl. Acad. Sci. U.S.A., 1988
Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism J. Pharmacol. Exp. Ther., 2010