phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate
phenylacetate + ATP + CoA-SH → phenylacetyl-CoA + AMP + PPi
- Reactome
- R-HSA-177157
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- phenylacetateCHEBI:8082, C8H8O2, mitochondrial matrix
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
Outputs
- phenylacetyl-CoACHEBI:57390, C29H38N7O17P3S, mitochondrial matrix
- AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
- PPiCHEBI:33019, HO7P2, mitochondrial matrix
Catalysed by
- CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
Literature
- Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids Biochim Biophys Acta, 1999
- Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria J Biochem Mol Toxicol, 2003
- Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product J Biol Chem, 2001