acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
ATP + CH3COO- + CoA-SH → Ac-CoA + AMP + PPi
- Reactome
- R-HSA-449911
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:23177
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- CH3COO-CHEBI:30089, C2H3O2, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
Outputs
- Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
- AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
- PPiCHEBI:33019, HO7P2, mitochondrial matrix
Catalysed by
- acetyl-CoA synthetase activity of ACSS1 [mitochondrial matrix]EC 6.2.1.1; UniProt Q9NUB1
Literature
- Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 Proc Natl Acad Sci U S A, 2006