Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP1A2 hydroxylates AFB1 to AFM1

AFB1 + H+ + NADPH + O2 → AFM1 + H2O + NADP+

Reactome: R-HSA-5423678
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

AFB1CHEBI:2504, C17H12O6, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

AFM1CHEBI:78576, C17H12O7, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]UniProt P05177

Literature

Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes Chem. Res. Toxicol., 1995