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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GLYAT-like proteins transfer glycine to ST-CoA to form SUA

ST-CoA + Gly → SUA + CoA-SH

Reactome: R-HSA-159574
Compartment: mitochondrial matrix
Rhea: RHEA:19870

Inputs

ST-CoACHEBI:32587, C28H40N7O18P3S, mitochondrial matrix
GlyCHEBI:57305, C2H5NO2, mitochondrial matrix

Outputs

SUACHEBI:9008, C9H9NO4, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

glycine N-benzoyltransferase activity of GLYAT-like proteins [mitochondrial matrix]EC 2.3.1.71

Literature

Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man J Biol Chem, 1976
Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver Biochem Biophys Res Commun, 1994