Coumarin is 7-hydroxylated by CYP2A13
COUM + O2 + NADPH + H+ → HCOU + H2O + NADP+
- Reactome
- R-HSA-211881
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen · smooth endoplasmic reticulum
- Rhea
- None recorded
Inputs
- COUMCHEBI:28794, C9H6O2, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Outputs
- HCOUCHEBI:27510, C9H6O3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
Catalysed by
- coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane]