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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP3A7 can 6beta-hydroxylate testosterone

TES + NADPH + H+ + O2 → 6BHT + H2O + NADP+

Reactome: R-HSA-211882
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

TESCHEBI:17347, C19H28O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

6BHTCHEBI:34477, C19H28O3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane]

Literature

Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus Res Commun Mol Pathol Pharmacol, 1998