UGTs transfer GlcA from UDP-GlcA to O-centre substrates

O-centre functional group substrate + UDP-GlcA → O-glucuronide + UDP

Reactome

R-HSA-174931

Compartment

endoplasmic reticulum lumen · endoplasmic reticulum membrane

Rhea

None recorded

Catalysed by

• glucuronosyltransferase activity of UGTs (O-GlcA forming) [endoplasmic reticulum membrane]EC 2.4.1.17

Literature

1. Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver. Biochem Pharmacol, 1996
2. Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes Drug Metab Dispos, 2006