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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

N-atom dealkylation of caffeine

CAF + O2 + NADPH + H+ → Paraxanthine + H2O + NADP+ + CH2O

Reactome: R-HSA-76426
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

CAFCHEBI:27732, C8H10N4O2, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen

Outputs

ParaxanthineCHEBI:25858, C7H8N4O2, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
CH2OCHEBI:16842, CH2O, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]UniProt P05177

Literature

Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine Xenobiotica, 1995