Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP4B1 12-hydroxylates ARA

AA + H+ + NADPH + O2 → 12-HETE + NADP+ + H2O

Reactome: R-HSA-211924
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

AACHEBI:32395, C20H31O2, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

12-HETECHEBI:19138, C20H32O3, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP4B1 based) [endoplasmic reticulum membrane]

Literature

Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids J Ocul Pharmacol Ther, 2004