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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SULT1A1 dimer sulfonates NHABP

NHABP + PAPS → NHABP-SO4 + PAP

Reactome: R-HSA-158860
Compartment: cytosol
Rhea: None recorded

Inputs

NHABPCHEBI:16580, C12H11NO, cytosol
PAPSCHEBI:58339, C10H11N5O13P2S, cytosol

Outputs

NHABP-SO4CHEBI:32701, C12H11NO4S, cytosol
PAPCHEBI:58343, C10H11N5O10P2, cytosol

Catalysed by

aryl sulfotransferase activity of SULT1A1 dimer [cytosol]EC 2.8.2.1

Literature

Sulfotransferase catalyzing sulfation of heterocyclic amines Cancer Lett, 1999
Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes FASEB J, 1997
Sulfonation and molecular action Endocr Rev, 2002