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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP1A2, 3A4 oxidise AFB1 to AFNBO

AFB1 + H+ + NADPH + O2 → AFNBO + H2O + NADP+

Reactome: R-HSA-5423672
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

AFB1CHEBI:2504, C17H12O6, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

AFNBOCHEBI:78586, C17H12O7, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP1A2,3A4 [endoplasmic reticulum membrane]

Literature

The endo-8,9-epoxide of aflatoxin B1: a new metabolite Chem. Res. Toxicol., 1992
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes Chem. Res. Toxicol., 1995