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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Unknown ALDH oxidizes 10-oxo-DECA

H2O + 10-oxo-DECA + NAD+ → 2 H+ + sebacate + NADH

Reactome: R-HSA-9971429
Compartment: cytosol
Rhea: RHEA:49833

Inputs

H2OCHEBI:15377, H2O, cytosol
10-oxo-DECACHEBI:58022, C10H17O3, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

2 H+CHEBI:15378, H, cytosol
sebacateCHEBI:76283, C10H16O4, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Catalysed by

aldehyde dehydrogenase (NAD+) activity of Unknown aldehyde dehydrogenase [cytosol]EC 1.2.1.3

Literature

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes Sci Rep, 2017
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization Biochim. Biophys. Acta, 1997