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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ESD dimer hydrolyses S-FGSH to GSH

S-FGSH + H2O → GSH + formate

Reactome: R-HSA-5693724
Compartment: endoplasmic reticulum lumen
Rhea: RHEA:14962

Inputs

S-FGSHCHEBI:16225, C11H17N3O7S, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

GSHCHEBI:16856, C10H17N3O6S, endoplasmic reticulum lumen
formateCHEBI:15740, CHO2, endoplasmic reticulum lumen

Catalysed by

S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]EC 3.1.2.12

Literature

Esterase D: a new human polymorphism Ann. Hum. Genet., 1973
Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells Hum. Genet., 1986