Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

ATP + CH3COO- + CoA-SH → AMP + PPi + Ac-CoA

Reactome: R-HSA-71735
Compartment: cytosol
Rhea: RHEA:23177

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
CH3COO-CHEBI:15366, C2H4O2, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol

Catalysed by

acetyl-CoA synthetase activity of ACSS2 [cytosol]EC 6.2.1.1; UniProt Q9NR19

Literature

Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem, 2000