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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDH1B1 tetramer oxidises CH3CHO to CH3COOH

CH3CHO + H2O + NAD+ → CH3COO- + H+ + NADH

Reactome: R-HSA-5696091
Compartment: mitochondrial matrix
Rhea: RHEA:25295

Inputs

CH3CHOCHEBI:15343, C2H4O, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

CH3COO-CHEBI:30089, C2H3O2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix

Catalysed by

aldehyde dehydrogenase (NAD+) activity of ALDH1B1 tetramer [mitochondrial matrix]EC 1.2.1.3

Literature

Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme Drug Metab. Dispos., 2010