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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP3A4, CYP2B6 bind ritonavir

CYP3A4, CYP2B6 + ritonavir → CYP3A4,CYP2B6:ritinovir

Reactome: R-HSA-9680865
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

CYP3A4, CYP2B6R-HSA-9680941, endoplasmic reticulum membrane
ritonavirR-ALL-9679091, cytosol

Outputs

CYP3A4,CYP2B6:ritinovirR-HSA-9680864, endoplasmic reticulum membrane

Literature

Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir Antimicrob. Agents Chemother., 2008
Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies Br J Clin Pharmacol, 2015
Mechanism-based inactivation of CYP3A by HIV protease inhibitors J. Pharmacol. Exp. Ther., 2005
Compounds with therapeutic potential against novel respiratory 2019 coronavirus Antimicrob. Agents Chemother., 2020
Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target EXCLI J, 2020
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 N. Engl. J. Med., 2020