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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GCL ligates L-Glu to L-Cys

L-Glu + L-Cys + ATP → gGluCys + ADP + Pi

Reactome: R-HSA-174367
Compartment: cytosol
Rhea: RHEA:13286

Inputs

L-GluCHEBI:29985, C5H8NO4, cytosol
L-CysCHEBI:35235, C3H7NO2S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

gGluCysCHEBI:58173, C8H13N2O5S, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

glutamate-cysteine ligase activity of GCL [cytosol]EC 6.3.2.2

Literature

Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues Biochem Biophys Res Commun, 1995
Expression and purification of human gamma-glutamylcysteine synthetase Protein Expr Purif, 1998