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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)

Acetaminophen (TN TYLENOL) + NADP+ + H2 + O2 → NABQI + H2O + NADPH

Reactome: R-HSA-76397
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

Acetaminophen (TN TYLENOL)CHEBI:46195, C8H9NO2, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2CHEBI:18276, H2, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

NABQICHEBI:29132, C8H7NO2, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Literature

Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation Clin Pharmacol Ther, 2000