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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IMPAD1 hydrolyses PAP to AMP

PAP + H2O → adenosine 5'-monophosphate + Pi

Reactome: R-HSA-8953499
Compartment: Golgi lumen
Rhea: RHEA:10041

Inputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
H2OCHEBI:15377, H2O, Golgi lumen

Outputs

adenosine 5'-monophosphateCHEBI:456215, C10H12N5O7P, Golgi lumen
PiCHEBI:43474, HO4P, Golgi lumen

Catalysed by

3'(2'),5'-bisphosphate nucleotidase activity of IMPAD1:Mg2+ [Golgi lumen]EC 3.1.3.7

Literature

Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis Proc. Natl. Acad. Sci. U.S.A., 2013