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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

lithocholate + PAPS => lithocholate sulfate + PAP

PAPS + LCA → PAP + lithocholate sulfate

Reactome: R-HSA-176588
Compartment: cytosol
Rhea: RHEA:51065

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
LCACHEBI:29744, C24H39O3, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
lithocholate sulfateCHEBI:133940, C24H38O6S, cytosol

Catalysed by

sulfotransferase activity of SULT2A1 dimer [cytosol]EC 2.8.2

Literature

Human liver steroid sulphotransferase sulphates bile acids Biochem J, 1990