Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP3A4 binds CYP3A4 inhibitors

CYP3A4 + CYP3A4 inhibitors → CYP3A4:CYP3A4 inhibitors

Reactome: R-HSA-9678766
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

CYP3A4R-HSA-52639, endoplasmic reticulum membrane
CYP3A4 inhibitorsR-ALL-9679016, cytosol

Outputs

CYP3A4:CYP3A4 inhibitorsR-HSA-9679000, endoplasmic reticulum membrane

Literature

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions Psychopharmacology (Berl.), 1999
Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies Br J Clin Pharmacol, 2015
Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes Br J Clin Pharmacol, 2001
Cobicistat, a pharmacoenhancer for HIV treatments Drugs Today, 2013
Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer ACS Med Chem Lett, 2010