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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

BIL + UDP-GlcA → BMG + UDP

Reactome: R-HSA-159194
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

BILCHEBI:57977, C33H34N4O6, endoplasmic reticulum lumen
UDP-GlcACHEBI:58052, C15H19N2O18P2, endoplasmic reticulum lumen

Outputs

BMGCHEBI:16427, C39H44N4O12, endoplasmic reticulum lumen
UDPCHEBI:58223, C9H11N2O12P2, endoplasmic reticulum lumen

Catalysed by

glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]EC 2.4.1.17; UniProt P22310

Literature

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man J Biol Chem, 1994
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini J. Biol. Chem., 1992
The hepatic microsomal formation of bilirubin diglucuronide J Biol Chem, 1983
Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography Hepatology, 1981
Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver J Hepatol, 1986
Bilirubin conjugates in bile of man and rat in the normal state and in liver disease J Clin Invest, 1972