CYP4V2 omega-hydroxylates DHA to HDoHE
DHA + H+ + NADPH + O2 → HDoHE + H2O + NADP+
- Reactome
- R-HSA-6786239
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- None recorded
Inputs
- DHACHEBI:77016, C22H31O2, endoplasmic reticulum membrane
- H+CHEBI:15378, H, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- O2CHEBI:15379, O2, cytosol
Outputs
- HDoHECHEBI:77015, C22H31O3, endoplasmic reticulum membrane
- H2OCHEBI:15377, H2O, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Catalysed by
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of CYP4V2 [e…EC 1.14.13; UniProt Q6ZWL3
Literature
- Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2 Am J Hum Genet, 2004
- Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase Drug Metab. Dispos., 2009
- CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant Mol. Pharmacol., 2012