CYP26A1,B1 4-hydroxylate atRA
atRA + NADPH + H+ + O2 → 4OH-atRA + H2O + NADP+
- Reactome
- R-HSA-212007
- Compartment
- endoplasmic reticulum membrane
- Rhea
- None recorded
Inputs
- atRACHEBI:15367, C20H28O2, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
Outputs
- 4OH-atRACHEBI:63795, C20H28O3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
Catalysed by
- retinoic acid 4-hydroxylase activity of CYP26A1,B1,C1 [endoplasmic reticulum membrane]
Literature
- Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells Cell Growth Differ, 1998
- Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism Proc Natl Acad Sci U S A, 2000