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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP2W1 oxidises INDOL

INDOL + NADPH + H+ + O2 → Oxindole + NADP+ + H2O

Reactome: R-HSA-211968
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

INDOLCHEBI:16881, C8H7N, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

OxindoleCHEBI:31697, C8H7NO, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2W1 based) [endoplasmic reticulum membrane]

Literature

Enzymatic properties of human CYP2W1 expressed in Escherichia coli Biochem Biophys Res Commun, 2006