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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Arrows follow Reactome's curated reaction direction.

CYP2C19 5-hydroxylates omeprazole

Losec + NADPH + H+ + O2 → HOMZ + NADP+ + H2O

Reactome: R-HSA-211929
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

LosecCHEBI:7772, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

HOMZCHEBI:63840, C17H19N3O4S, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane]

Literature

Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity J Biol Chem, 1996