Unknown CYP 450 omega-hydroxylates C10 fatty acid
O2 + NADPH + DECA → H2O + NADP+ + 10-OH-DECA + H+
- Reactome
- R-HSA-9971246
- Compartment
- smooth endoplasmic reticulum
- Rhea
- RHEA:75284
Inputs
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- DECACHEBI:27689, C10H19O2, endoplasmic reticulum lumen
Outputs
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- 10-OH-DECACHEBI:11305, C10H19O3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of Unknown Cytochrome P450-like monooxygenase [endoplasmic reticulum membrane]
Literature
- Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes Arch Biochem Biophys, 1996
- On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver Pediatr Res, 1983