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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

N-hydroxy-2-acetylaminofluorene + PAPS → AAF-N-S + PAP

Reactome: R-HSA-176669
Compartment: cytosol
Rhea: None recorded

Inputs

N-hydroxy-2-acetylaminofluoreneCHEBI:17931, C15H13NO2, cytosol
PAPSCHEBI:58339, C10H11N5O13P2S, cytosol

Outputs

AAF-N-SCHEBI:35424, C15H13NO5S, cytosol
PAPCHEBI:58343, C10H11N5O10P2, cytosol

Catalysed by

sulfotransferase activity of SULTs active on NH2AAF [cytosol]EC 2.8.2

Literature

Sulfotransferases in the bioactivation of xenobiotics Chem Biol Interact, 2000
Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene J Biol Chem, 1998