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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AOC2 deaminates TYR

TYR + H2O + O2 → 4HPAA + NH3 + H2O2 + H+

Reactome: R-HSA-5696146
Compartment: extracellular region · plasma membrane
Rhea: RHEA:30592

Inputs

TYRCHEBI:15760, C8H11NO, extracellular region
H2OCHEBI:15377, H2O, extracellular region
O2CHEBI:15379, O2, extracellular region

Outputs

4HPAACHEBI:15621, C8H8O2, extracellular region
NH3CHEBI:16134, H3N, extracellular region
H2O2CHEBI:16240, H2O2, extracellular region
H+CHEBI:15378, H, extracellular region

Catalysed by

primary methylamine oxidase activity of AOC2 [plasma membrane]EC 1.4.3.21; UniProt O75106

Literature

Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes Biochimie, 2007
The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase Cell. Mol. Life Sci., 2009