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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP

PAPS + DHEA → PAP + DHEA-SO4

Reactome: R-HSA-176631
Compartment: cytosol
Rhea: RHEA:51217

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
DHEACHEBI:28689, C19H28O2, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
DHEA-SO4CHEBI:57905, C19H27O5S, cytosol

Catalysed by

steroid sulfotransferase activity of SULTs active on DHEA [cytosol]EC 2.8.2.15

Literature

Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b) J Steroid Biochem Mol Biol, 2001
Human liver estrogen sulfotransferase: identification by cDNA cloning and expression Biochem Biophys Res Commun, 1994
Human liver steroid sulphotransferase sulphates bile acids Biochem J, 1990