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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MARC1,MARC2 reduce N-hydroxylated compounds

NOHA + H+ + NADH → L-Arg + NAD+ + H2O

Reactome: R-HSA-8936442
Compartment: cytosol · mitochondrial outer membrane
Rhea: None recorded

Inputs

NOHACHEBI:47823, C6H14N4O3, cytosol
H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Outputs

L-ArgCHEBI:32682, C6H15N4O2, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

oxidoreductase activity of MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3 [mitochondrial outer membrane]EC 1

Literature

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs J. Med. Chem., 2008
Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians Drug Metab. Dispos., 2014
The mammalian molybdenum enzymes of mARC J. Biol. Inorg. Chem., 2015
The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice PLoS ONE, 2014