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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

N-hydroxylation of 4-aminobiphenyl

ABPH + O2 + NADPH + H+ → NHABP + H2O + NADP+

Reactome: R-HSA-76373
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

ABPHCHEBI:1784, C12H11N, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen

Outputs

NHABPCHEBI:16580, C12H11NO, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]UniProt P05177

Literature

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes Carcinogenesis, 1997
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon Carcinogenesis, 1991