GST trimers transfer GS from GSH to luminal substrates

electrophilic substrate + GSH → electrophilic substrate:SG

Reactome

R-HSA-176059

Compartment

endoplasmic reticulum lumen · endoplasmic reticulum membrane

Rhea

None recorded

Catalysed by

• glutathione transferase activity of MGST trimers [endoplasmic reticulum membrane]EC 2.5.1.18

Literature

1. Gene expression of rat and human microsomal glutathione S-transferases J. Biol. Chem., 1988
2. Structural organization of the human microsomal glutathione S-transferase gene (GST12) Genomics, 1996
3. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase J. Biol. Chem., 1996
4. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities J. Biol. Chem., 1997
5. The 3-D structure of microsomal glutathione transferase 1 at 6 A resolution as determined by electron crystallography of p22(1)2(1) crystals Biochim. Biophys. Acta, 2002