Vinyl chloride is oxidized to 2-Chloroethylene oxide
VC + NADPH + H+ + O2 → H2O + NADP+ + 2CEO
- Reactome
- R-HSA-76354
- Compartment
- smooth endoplasmic reticulum
- Rhea
- None recorded
Inputs
- VCCHEBI:28509, C2H3Cl, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
Outputs
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- 2CEOCHEBI:29129, C2H3ClO, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]