Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP27A1 27-hydroxylates CHOL

CHOL + NADPH + H+ + O2 → 27OH-CHOL + H2O + NADP+

Reactome: R-HSA-192123
Compartment: mitochondrial matrix
Rhea: RHEA:43837

Inputs

CHOLCHEBI:16113, C27H46O, mitochondrial matrix
NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
O2CHEBI:15379, O2, mitochondrial matrix

Outputs

27OH-CHOLCHEBI:17703, C27H46O2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix
NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix

Catalysed by

oxidoreductase activity, acting on NAD(P)H as acceptor of CYP27A1 [mitochondrial matrix]EC 1.6.1; UniProt Q02318

Literature

Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J Biol Chem, 1991