CYP2J2 oxidises ARA

AA + NADPH + H+ + O2 → cis-EET + NADP+ + H2O

Reactome

R-HSA-211983

Compartment

smooth endoplasmic reticulum

Rhea

None recorded

Catalysed by

• arachidonate epoxygenase activity of Cytochrome P450 (CYP2J2 based) [endoplasmic reticulum membrane]

Literature

1. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance Mol Pharmacol, 1996
2. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart J Biol Chem, 1996