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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CES3 hydrolyses CHEST to CHOL and LCFA(-)

H2O + CHEST → CHOL + LCFA(-)

Reactome: R-HSA-8937442
Compartment: cytosol · lipid droplet · transport vesicle membrane
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, cytosol
CHESTCHEBI:17002, C28H45O2R, lipid droplet

Outputs

CHOLCHEBI:16113, C27H46O, transport vesicle membrane
LCFA(-)CHEBI:57560, CO2R, cytosol

Catalysed by

carboxylic ester hydrolase activity of CES3 [cytosol]EC 3.1.1.1; UniProt Q6UWW8

Literature

Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing Am. J. Physiol., Cell Physiol., 2012
Mammalian carboxylesterase 3: comparative genomics and proteomics Genetica, 2010