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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

AFB1 + H+ + NADPH + O2 → AFXBO + H2O + NADP+

Reactome: R-HSA-156526
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

AFB1CHEBI:2504, C17H12O6, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

AFXBOCHEBI:30725, C17H12O7, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP1A2,3A4,3A5,2A13 [endoplasmic reticulum membrane]

Literature

The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 Toxicol. Appl. Pharmacol., 1996
Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract Int. J. Cancer, 2006