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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

The acetyl group from acetyl-CoA is transferred to NAT1

NAT1 + Ac-CoA → AcC-NAT1 + CoA-SH

Reactome: R-HSA-174959
Compartment: cytosol
Rhea: None recorded

Inputs

NAT1R-HSA-174956, cytosol
Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol

Outputs

AcC-NAT1R-HSA-174972, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

protein-cysteine S-acyltransferase activity of NAT1 [cytosol]EC 2.3.1; UniProt P18440

Literature

Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2. J Biol Chem, 1992